What is the 2-Amino-3-benzyloxypyridine?

2-Amino-3-benzyloxypyridine is white to yellowish crystal, while it's Molecular Formula is C12H12N2O. white to yellowish crystal 2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.

What is the CAS number for 2-Amino-3-benzyloxypyridine?

The CAS number of 2-Amino-3-benzyloxypyridine is 24016-03-3.

What is 2-Amino-3-benzyloxypyridine (24016-03-3) used for?

2-Amino-3-benzyloxypyridine is an organic compound characterized by its brown crystalline powder form. It is a key intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting Raf kinase, which plays a significant role in cell signaling and is associated with several diseases, including cancer.InChI:InChI=1/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)/p+1

What is the 2-Amino-3-benzyloxypyridine?

2-Amino-3-benzyloxypyridine is white to yellowish crystal, while it's Molecular Formula is C12H12N2O. white to yellowish crystal 2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.

What is the CAS number for 2-Amino-3-benzyloxypyridine?

The CAS number of 2-Amino-3-benzyloxypyridine is 24016-03-3.

What is 2-Amino-3-benzyloxypyridine (24016-03-3) used for?

2-Amino-3-benzyloxypyridine is an organic compound characterized by its brown crystalline powder form. It is a key intermediate in the synthesis of various pharmaceutical compounds, particularly those targeting Raf kinase, which plays a significant role in cell signaling and is associated with several diseases, including cancer.InChI:InChI=1/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)/p+1

2-Amino-3-benzyloxypyridine

Buy reliable Quality 2-Amino-3-benzyloxypyridine 24016-03-3 raw material with Honest Price

Molecular Formula:C12H12N2O
Molecular Weight:200.24
Appearance/Colour:white to yellowish crystal
Vapor Pressure:2.02E-05mmHg at 25°C
Melting Point:92-94 °C(lit.)
Refractive Index:1.6660 (estimate)
Boiling Point:361.8 °C at 760 mmHg
PKA:8.40±0.10(Predicted)
Flash Point:172.6 °C
PSA：48.14000
Density:1.18 g/cm³
LogP:2.82400

2-Amino-3-benzyloxypyridine(Cas 24016-03-3) Usage

Biochem/physiol Actions	2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.
General Description	2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.

InChI:InChI=1/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)/p+1

24016-03-3 Relevant articles

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons

Baggelaar, Marc P.,Chameau, Pascal J. P.,Kantae, Vasudev,Hummel, Jessica,Hsu, Ku-Lung,Janssen, Freek,Van Der Wel, Tom,Soethoudt, Marjolein,Deng, Hui,Den Dulk, Hans,Allarà, Marco,Florea, Bogdan I.,Di Marzo, Vincenzo,Wadman, Wytse J.,Kruse, Chris G.,Overkleeft, Herman S.,Hankemeier, Thomas,Werkman, Taco R.,Cravatt, Benjamin F.,Van Der Stelt, Mario

, p. 8851 - 8857 (2015)

Diacylglycerol lipase (DAGL)-α and -β ar...

Multi-substituted amine compound and its preparation and use (by machine translation)

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Paragraph 0927; 0928; 0930; 0931, (2018/04/27)

The invention belongs to the field of me...

Preparation method of high-purity paliperidone intermediate

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Paragraph 0035-0036, (2017/11/18)

The invention belongs to the technical f...

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction

Elkamhawy, Ahmed,Park, Jung-eun,Hassan, Ahmed H.E.,Ra, Hyunhwa,Pae, Ae Nim,Lee, Jiyoun,Park, Beoung-Geon,Moon, Bongjin,Park, Hyun-Mee,Roh, Eun Joo

, p. 56 - 69 (2017/02/05)

Herein, we report a new series of alipha...

COMPOUND, COMPOSITIONS, AND METHODS

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Page/Page column 243, (2017/08/01)

Compounds having activity as LRRK2 inhib...

24016-03-3 Process route

: 16867-03-1
2-amino-3-hydroxypyridine

: 100-44-7
benzyl chloride

: 24016-03-3
2-amino-3-benzyloxypyridine

Conditions

Conditions	Yield
at 20 ℃;	90%
With sodium hydroxide; Adogen 464<*>; In dichloromethane; at 25 ℃; for 16h;	77%
With tetrabutylammomium bromide; sodium hydroxide; In water; at 40 - 75 ℃; for 6h; Large scale;	77.3%
With sodium hydroxide; adogen 464; In dichloromethane; Ambient temperature;	75%
With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 20 ℃; for 19h;	60%
With sodium hydroxide; tetrabutylammomium bromide; In water; at 20 ℃; for 16h;	49%
With sodium hydroxide; In ethanol; dichloromethane;
With sodium hydroxide; Adogen 464; In dichloromethane; water; at 20 ℃; for 19h;
With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 20 ℃; for 6h;

: 16867-03-1
2-amino-3-hydroxypyridine

: 100-39-0
benzyl bromide

: 24016-03-3
2-amino-3-benzyloxypyridine

Conditions

Conditions	Yield
With caesium carbonate; In N,N-dimethyl-formamide;	56%
2-amino-3-hydroxypyridine; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 25 - 30 ℃; for 0.25h; Inert atmosphere; Schlenk technique; benzyl bromide; In dichloromethane; water; at 25 ℃; for 18h; Inert atmosphere; Schlenk technique;
With caesium carbonate; In N,N-dimethyl-formamide;
2-amino-3-hydroxypyridine; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 20 ℃; for 0.25h; Inert atmosphere; Schlenk technique; benzyl bromide; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere; Schlenk technique;