What is the 4-Amino-2-(trifluoromethyl)benzonitrile?

4-Amino-2-(trifluoromethyl)benzonitrile is white powder, while it's Molecular Formula is C8H5F3N2. white powder 4-Amino-2-(trifluoromethyl)benzonitrile can serve as starting material in the synthesis of benzimidazoles, which can act as potential candidates in the treatment of breast cancer due to their ability to inhibit the growth of endothelial cells.

What is the CAS number for 4-Amino-2-(trifluoromethyl)benzonitrile?

The CAS number of 4-Amino-2-(trifluoromethyl)benzonitrile is 654-70-6.

What is the 4-Amino-2-(trifluoromethyl)benzonitrile?

4-Amino-2-(trifluoromethyl)benzonitrile is white powder, while it's Molecular Formula is C8H5F3N2. white powder 4-Amino-2-(trifluoromethyl)benzonitrile can serve as starting material in the synthesis of benzimidazoles, which can act as potential candidates in the treatment of breast cancer due to their ability to inhibit the growth of endothelial cells.

What is the CAS number for 4-Amino-2-(trifluoromethyl)benzonitrile?

The CAS number of 4-Amino-2-(trifluoromethyl)benzonitrile is 654-70-6.

4-Amino-2-(trifluoromethyl)benzonitrile

Q: What is 4-Amino-2-(trifluoromethyl)benzonitrile (654-70-6) used for?

4-Amino-2-(trifluoromethyl)benzonitrile is an organic compound characterized by its off-white solid appearance. It is a derivative of benzonitrile with an amino group at the 4th position and a trifluoromethyl group at the 2nd position, which contributes to its unique chemical properties and potential applications.InChI:InChI=1/C8H5F3N2/c9-8(10,11)7-3-6(13)2-1-5(7)4-12/h1-3H,13H2

Perfect Factory Offer Excellent quality 4-Amino-2-(trifluoromethyl)benzonitrile 654-70-6 with Safe Shipping

Molecular Formula: C8H5F3N2
Molecular Weight: 186.136
Appearance/Colour: white powder
Vapor Pressure: 0.00162mmHg at 25°C
Melting Point: 136-145 °C
Refractive Index: 1.499
Boiling Point: 294.5 °C at 760 mmHg
PKA: 0.50±0.10(Predicted)
Flash Point: 131.9 °C
PSA： 49.81000
Density: 1.37 g/cm³
LogP: 2.74048

4-Amino-2-(trifluoromethyl)benzonitrile(Cas 654-70-6) Usage

InChI:InChI=1/C8H5F3N2/c9-8(10,11)7-3-6(13)2-1-5(7)4-12/h1-3H,13H2

654-70-6 Relevant articles

High Turnover Pd/C Catalyst for Nitro Group Reductions in Water. One-Pot Sequences and Syntheses of Pharmaceutical Intermediates

Gallou, Fabrice,Li, Xiaohan,Lipshutz, Bruce H.,Takale, Balaram S.,Thakore, Ruchita R.

supporting information, p. 8114 - 8118 (2021/10/25)

Commercially available Pd/C can be used ...

Late-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

Thakore, Ruchita R.,Takale, Balaram S.,Singhania, Vani,Gallou, Fabrice,Lipshutz, Bruce H.

, p. 212 - 216 (2020/12/01)

New technology is described that enables...

Preparation method of 4-amino-2-trifluoromethyl benzonitrile

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Paragraph 0036; 0044-0046; 0047; 0053-0054, (2020/05/14)

The invention relates to the technical f...

Method for synthesizing 4- amino -2- trifluoromethyl cyanobenzene

-

Paragraph 0023-0028, (2020/03/16)

The method 4 - comprises the following s...

654-70-6 Process route

: 155403-06-8
3-(trifluoromethyl)-4-iodobenzenamine

: 124-38-9,18923-20-1
carbon dioxide

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; copper(I) oxide; phenylsilane; ammonia; at 180 ℃; for 20h; under 2280.15 Torr; chemoselective reaction; Sealed tube;	76%
With ammonia; hydrogen; copper diacetate; In N,N-dimethyl-formamide; at 160 ℃; for 10h; Sealed tube;	74 %Chromat.

: 934600-95-0
4-amino-2-trifluoromethylbenzamide

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

Conditions

Conditions	Yield
With thionyl chloride; In toluene; at 60 ℃; for 5h; Temperature; Solvent;	92%

654-70-6 Upstream products

320-41-2
4-chloro-2-(trifluoromethyl)benzonitrile
544-92-3
copper(I) cyanide
393-36-2
4-bromo-3-(trifluoromethyl)aniline
97760-99-1
C₁₀H₇F₃N₂O

654-70-6 Downstream products

113181-02-5
(S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide
90356-00-6
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[phenylthio]-2-hydroxy-2-methyl-propanamide
90356-39-1
N-(4-Cyano-3-trifluoromethyl-phenyl)-3,3,3-trifluoro-2-hydroxy-2-propylsulfanylmethyl-propionamide
90356-77-7
3-(4-Chloro-phenylsulfanyl)-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methyl-propionamide