Drospirenone
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1.What is the Drospirenone ?
Drospirenone has been used as a progestogen agent in pond snail and fish.
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6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4,20-diene-21,17-carbolactone
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-
90457-65-1,93920-59-3,67372-75-2,67392-87-4
dihydrospirorenone
| Conditions | Yield |
|---|---|
|
With
hydrogen;
platinum on carbon;
In
ethyl acetate;
for 1h;
under 75.0075 Torr;
Inert atmosphere;
|
90%
|
-
-
6β,7β;15β,16β-dimethylene-17β-dihydroxy-17α-(2-ethoxycarbonyl)-ethyl-androst-4-en-3-one
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-
90457-65-1,93920-59-3,67372-75-2,67392-87-4
dihydrospirorenone
| Conditions | Yield |
|---|---|
|
With
water; potassium carbonate;
In
methanol;
at 20 ℃;
for 0.5h;
|
66%
|
|
With
toluene-4-sulfonic acid;
In
ethyl acetate;
at 20 ℃;
for 1h;
|
2.What is the CAS number for Drospirenone ?
The CAS number of Drospirenone is 67392-87-4.
More information of Drospirenone 67392-87-4 are:
|
CAS?Number |
67392-87-4 |
|
Density |
1.26 g/cm3 |
|
Melting Point |
196-200 °C |
|
Boiling Point |
552.2 °C at 760 mmHg |
|
Flash Point |
241.6 °C |
|
Vapor Pressure |
3.07E-12mmHg at 25°C |
|
Refractive Index |
1.61 |
|
HS CODE |
2937230000 |
|
PSA |
43.37000 |
|
LogP |
4.30590 |
3.What are another words for Drospirenone ?
Synonyms?for?Drospirenone 67392-87-4:Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione,1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-,[6R-(6a,7a,8b,9a,10b,13b,14a,15a,16a,17b)]-;1,2-Dihydrospirorenone;6b,7b:15b,16b-Dimethylene-3-oxo-17a-pregn-4-ene-21,17-carbolactone;Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione,1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-,(2'S,6R,7R,8R,9S,10R,13S,14S,15S,16S)-;Dehydrospirorenone;Drospirenona;
4.What is the molecular formula of Drospirenone?
The chemical formula of ?Drospirenone is?C24 H30 O3 which containing 24 Carbon atoms,30 Hydrogen atoms and 3 Oxygen atoms,and the molecular weight of??Drospirenone?is 366.5.
5.What is Drospirenone (67392-87-4) used for?
The steroid drospirenone in combination with the estrogen agonist ethinylestradiol was introduced in Germany as a new oral contraceptive for women. This analog of the aldosterone antagonist spironoiactone can be synthesized in five steps from 3β-hydroxy- 15β,16β-methylene-5-androsten-l7-one. Since its binding profile for steroid receptors is very similar to progesterone, drospirenone mimics the progestogen agonistic activity as well as the anti-androgenic and anti-mineralocorticoid properties of the endogenous hormone. In rats, drospirenone inhibited ovulation at 6.3 mglkglday p.o. Compared with currently available progestins which lack anti-mineralocorticoid activity, drospirenone did not cause weight gain that could result from fluid retention in clinical studies. Its combination with ethinylestradiol was well tolerated and did not engender adverse effects on blood pressure or plasma lipid levels. Drospirenone is rapidly absorbed in man with an oral bioavailability of 76%. It is extensively metabolized since over 20 different metabolites were observed in the urine and in the feces, resulting for instance from hydrolysis of the lactone in the plasma or reductive conjugation of the enone to the 3-sulfate ester of 45 dihydrodrospirenone. Its elimination is bi-exponential with an initial and a terminal half-life of 2 and 25-33h respectively.
InChI:InChI=1/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
Relevant articles related to Drospirenone:
|
Article |
Source |
|
A drospirenone and intermediate preparation method (by machine translation) |
- , (2019/11/20) |
|
PROCESS FOR THE PREPARATION OF DROSPIRENONE |
- Page/Page column 11, (2014/10/29) |
6.Buy Drospirenone with the best price .
Shanghai Yolne Chemical Co., Ltd(expird) is a quality supplier of Drospirenone. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Drospirenone 67392-87-4.
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