BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
Contact usChina cas 486460-00-8 manufacturer wholesale BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID at affordable price
- Molecular Formula: C15H18F3NO4
- Molecular Weight: 333.307
- Vapor Pressure: 1.25E-08mmHg at 25°C
- Melting Point: 136-138℃
- Refractive Index: 1.494
- Boiling Point: 443.1 °C at 760 mmHg
- PKA: 4.30±0.10(Predicted)
- Flash Point: 221.8 °C
- PSA： 75.63000
- Density: 1.292 g/cm3
- LogP: 3.40530
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID(Cas 486460-00-8) Usage
|
Physical Form |
White to Yellow Solid |
InChI:InChI=1/C15H18F3NO4/c1-15(2,3)23-14(22)19-9(6-13(20)21)4-8-5-11(17)12(18)7-10(8)16/h5,7,9H,4,6H2,1-3H3,(H,19,22)(H,20,21)/t9-/m1/s1
486460-00-8 Relevant articles
Application of the asymmetric hydrogenation of enamines to the preparation of a beta-amino acid pharmacophore
Kubryk, Michele,Hansen, Karl B.
, p. 205 - 209 (2006)
(3R)-3-[N-(tert-Butoxycarbonyl)amino]-4-...
Nickel-Catalyzed Asymmetric Hydrogenation for the Synthesis of a Key Intermediate of Sitagliptin
Sudhakaran, Shana,Shinde, Prasad G.,Aratikatla, Eswar K.,Kaulage, Sandeep H.,Rana, Priksha,Parit, Ratan S.,Kavale, Dattatry S.,Senthilkumar, Beeran,Punji, Benudhar
supporting information, (2021/12/09)
Nickel-catalyzed enantioselective hydrog...
Preparation method of chiral 4 - aryl - β β-amino acid derivative
-
Paragraph 0056-0058, (2021/11/14)
Provided is a method for preparing a chi...
Synthesis of (?)-(R)-Sitagliptin by RhI-Catalyzed Asymmetric Hydroamination
Berthold, Dino,Breit, Bernhard
, p. 6247 - 6249 (2021/09/25)
We report of a concise synthesis of (R)-...
Preparation method of 1-morpholinyl-4-(2,4,5-trifluorophenyl)butane-1,3-dione
-
Paragraph 0087-0088; 0091, (2020/05/02)
The invention discloses a preparation me...
486460-00-8 Process route
-
-
936630-57-8
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
-
-
24424-99-5
di-tert -butyl dicarbonate
-
![(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid](/upload/2026/10/64db205d859547adae09506017ec1037_3f75279c-9a71-400f-9a8c-68de680c6670.png)
-
486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
1,4-dioxane; water;
at 20 ℃;
|
91%
|
|
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid;
With
lithium hydroxide;
In
1,4-dioxane; water;
at 0 - 30 ℃;
di-tert-butyl dicarbonate;
In
1,4-dioxane; water;
at 25 - 30 ℃;
|
91%
|
|
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 24h;
|
91%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
|
85%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 10h;
|
81.7%
|
|
In
tetrahydrofuran;
|
60.6%
|
|
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
|
14 g
|
|
With
sodium hydrogencarbonate;
In
methanol;
at 0 - 20 ℃;
for 6h;
|
|
|
With
sodium carbonate;
In
tetrahydrofuran; water;
at 25 - 30 ℃;
|
30 g
|
|
In
water;
at 20 ℃;
|
88.8 g
|
|
With
sodium hydroxide;
In
water;
at 25 - 30 ℃;
|
|
|
With
sodium hydroxide;
In
water;
at 25 - 30 ℃;
|
-
-
1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
-
-
486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid
| Conditions | Yield |
|---|---|
|
With
sodium hypochlorite; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
water; acetonitrile;
at 38 ℃;
for 0.333333h;
Solvent;
|
98%
|
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide;
In
dichloromethane;
at 0 ℃;
for 2h;
|
90%
|
|
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate;
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide;
In
dichloromethane;
at 0 ℃;
for 2h;
With
hydrogenchloride;
In
dichloromethane; water;
pH=2 - 3;
|
90%
|
|
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
|
90%
|
486460-00-8 Upstream products
-
486460-25-7
[3-diazo-2-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert -butyl ester
-
936630-57-8
(R)-3-amino-4-phenyl(2,4,5-trifluorophenyl)butanoic acid
-
24424-99-5
di-tert -butyl dicarbonate
-
881995-73-9
3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester
486460-00-8 Downstream products
-
486460-23-5
(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
-
1025933-74-7
[3-oxo-3-(3-pentafluoroethyl-5,6-dihydro-8H -[1,2,4]triazolo[4,3-a ]pyrazin-7-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert -butyl ester
-
1025950-29-1
[3-(5,6-dihydro-8H -[1,2,4]triazolo[4,3-a ]pyrazin-7-yl)-3-oxo-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert -butyl ester
-
892113-81-4
(3R)-4-[(3R)-3-(tert-butyloxycarbonylamino)-4-(2,4,5-trifluorophenyl) butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepin-2-one
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